Regulation of membrane-type 1 matrix metalloproteinase activity by vacuolar H+-ATPases
نویسندگان
چکیده
منابع مشابه
Regulation of membrane-type 1 matrix metalloproteinase activity by vacuolar H+-ATPases.
Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a key enzyme in normal development and malignant processes. The regulation of MT1-MMP activity on the cell surface is a complex process involving autocatalytic processing, tissue inhibitor of MMPs (TIMP) binding and constitutive internalization. However, the fate of internalized MT1-MMP is not known. Acidification of intracellular vacuolar c...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2003
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj20030170